Role of von Willebrand factor associated to extracellular matrices in platelet adhesion
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منابع مشابه
Role of von Willebrand factor associated to extracellular matrices in platelet adhesion.
The respective role of plasmatic and endothelial extracellular matrix (ECM)-associated von Willebrand factor (vWF) in platelet adhesion was investigated at a high shear rate using a parallel-plate perfusion chamber. Incubation of the endothelial ECM with a monoclonal antibody (MoAb) to vWF, which specifically blocks vWF binding to platelet GP Ib (MoAb 322), inhibited 45% of platelet adhesion. C...
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Platelet adhesion to fibrin at high shear rates depends on both the glycoprotein (GP) 1lb:llla complex and a secondary interaction between GPlb and von Willebrand factor (vWF). This alternative link between platelets and vWF in promoting platelet adhesion to fibrin has been examined in flowing whole blood with a rectangular perfusion chamber. Optimal adhesion required both platelets and vWF, as...
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ژورنال
عنوان ژورنال: Blood
سال: 1991
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v77.3.519.519